What is a Migraine?

Recent scientific evidence suggests that migraine headaches begin with a release of proteins by nerve endings in the fibrous outer covering of the brain (called the dura mater) resulting in the dilation of the cranial blood vessels following an initial contraction. During a migraine, inflammation of the tissue surrounding the brain exacerbates the pain.

Unlike most other types of headaches, migraines may have many additional symptoms. Migraines are sometimes preceded by visual auras. Following the onset of a migraine attack, symptoms may include throbbing, nausea, sensitivity to light and/or sound, difficulty in speech and semi-hemispheric head pain. A migraine attack can last for hours or days. Approximately three out of four migraine sufferers are female, and both the etiology and incidence of migraine attacks vary with the individual.

What Causes Migraine Headaches?

Migraines may be caused by a number of things. Frequently the cause is unknown, but triggers may include stress, anxiety, depression, particular foods, or alcohol. Hormones are also common triggers – many women experience migraines with changes in their estrogen levels during menstruation.

How Many People are affected by Migraine Headaches?

It is estimated that 32 million Americans, or nearly 12% of the population, suffer from migraine headaches. According to the American Council for Headache Education, nearly 3% of all men and upwards of 9% of all women suffer from migraine headaches.

Is a Migraine Headache simply a Severe Headache?

No. There are other forms of headaches such as tension headaches, which may actually be as severe as some migraines. The following symptoms may accompany a migraine headache:

  • Intense pain, Frequently Throbbing, Sometimes Localized on One Side of the Head
  • Sensitivity to Light (Photophobia)
  • Sensitivity to Noise
  • Nausea
  • Vomiting
  • Disturbed Vision
  • Slurred Speech

Some of these symptoms may also be indicative of other more serious conditions. If you are not certain if you are a migraine sufferer, consult your physician.

Are There Different Types of Migraines?

The two most prevalent types of migraine headaches are migraines with aura and migraine without aura, the latter of the two being more common.

What is a Migraine Aura?

Most often, a migraine aura consists of visual disturbances such as flashing lights, visual distortion, and spots before the eyes.

Is it a Migraine or a Sinus Headache?

Migraine headaches are often confused with sinus headaches because migraine pain often occurs in the sinus region. If your headache is caused by sinus blockage, such as an infection, you will probably have a fever or nasal discharge.


Migraine Risks and Prevention

You May Be At Risk


A recent study published in the Journal of the American Medical Association (JAMA) suggests that some patients with migraine with and without aura are at increased risk for sub-clinical lesions in certain brain areas. Brain lesions have been shown to increase the risk of stroke, physical limitations and cognitive impairment, including dementia. The results of the study suggest that patients with migraine with aura and a high attack frequency (one or more per month) are at increased risk of lesions. Additionally, women, but not men, with migraine with and without aura are also at increased risk. In both groups, the risk increases with increasing attack frequency.


A separate study published in the British Medical Journal (BMJ) demonstrated that migraine may be an independent risk factor for stroke. The magnitude of this risk remained the same for those suffering from migraine with aura and migraine without aura. Women who were users of oral contraceptives have shown that those with a history of migraines have twice the likelihood of developing an ischaemic stroke compared with those without migraines.


Medication Overuse Headache (MOH) is a frequent headache caused by overuse of medication, particularly those that treat migraines. Although evidence suggests that frequent use of analgesics may not cause MOH in everyone, overuse of medications by migraine sufferers is often found to increase the frequency of attacks. Studies have shown that a number of medications may cause MOH and that only by discontinuing the use of such medications can the symptoms of MOH be avoided. These medications include:

  • Triptans
  • Ergotamines
  • Common analgesics such as acetaminophen.
  • Opioids
  • Combination medications such as
    • Butalbital compounds containing aspirin or acetaminophen, butalbital, and caffeine.
    • Vicodin
    • Other compounds containing more than one medication.

MigraSpray and the ingredients within its proprietary formulation have not been shown to cause MOH and can be used as frequently as necessary to effectively prevent and treat migraine. It is not known whether MigraSpray is effective for treating the acute symptoms of MOH. A patient suffering from MOH that continues taking medications that may cause or contribute to MOH may not receive maximum benefit from MigraSpray. In order to obtain the best results it is recommended that the migraine sufferer begin using MigraSpray and gradually decrease their dosages of medications that may contribute to MOH until use of those medications has been discontinued.

MigraSpray Proven Effective


MigraSpray was shown to be highly effective in preventing migraines in a study of patients suffering from frequent migraines conducted by Dr. Fred Pescatore, Director of the Centers for Integrative and Complementary Medicine in New York City and Dallas. The participants in the study used MigraSpray each day and approximately 90% had their migraine attacks eliminated as long as they continued with regular daily usage.


Menstrual Migraine

Migraine is a significant women’s health concern. Each year the lives of millions of women are adversely affected by migraine pain which oftentimes also impacts the lives of their children, families, colleagues, and friends. Nearly 20% of women have experienced migraine pain at some point in their lives. Women typically experience their first migraine between 13 and 17 years of age and following menopause most women cease to suffer from migraine pain. But during these valuable years in a woman’s life, migraine causes substantial suffering and disability and gives rise to great economic and personal burden.

Many experts believe that migraines are caused, at least in part, to hormonal fluctuations including the monthly rise and fall of estrogen levels. Sixty percent of women who suffer from migraine headaches report an increase in headache frequency during their menstrual period.

Outside factors may also be to blame. Common migraine triggers include stress; foods such as chocolate, alcohol and citrus fruits; changes in altitude, climate or time zones; bright lights, physical exertion, and even air pollution. Avoiding such triggers is generally the first step in preventative care for migraines.

MigraSpray can be used on a daily basis for prevention in order to dramatically reduce or even eliminate migraine headaches (including menstrual migraines) with no risk of side effects or Medication Overuse Headache (MOH).